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Immunosenescence is associated with dysregulated signaling pathways (e.g., overactivation of the NF-B signaling pathway and downregulation of the melatonin signaling pathway) and abnormal immune cell responses with functional alterations and phenotypic shifts

While these changes typically require extended exposure at high levels, they represent a real risk of excessive or prolonged use

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Disorganized collagen provides less structural support and more uneven skin texture