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Technological progress, widespread exposure to artificial lighting in the evening and nighttime hours with low exposure to sunlight during the day, lack of physical activity, prolonged mental activity during the day and often also in the period immediately preceding going to sleep, irregular meal times, shift work and/or irregular work rhythms cause circadian rhythm sleep-wake disorders manifested, among other things, by poor sleep quality and decreased psychophysical performance during the day, to be common health problems in developed countries
Changes in genetics encompass MET exon 14 skipping mutations (METex14), amplification of MET genes, increased c-MET protein levels, structural domain mutations in MET kinase, and fusion of MET genes [22]
