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The mix of an initial high dose and weekly shots for a month is a strong way to manage the deficiency

People on vegan or strict plant-based diets need a reliable source from fortified foods (nutritional yeast, fortified plant milks, certain breakfast cereals) or a supplement

The peptidomimetic design often incorporates D-amino acids or non-natural backbones to resist enzymatic breakdown, extending its circulation time in the blood to allow for "homing" to adipose tissue