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While oral administration peaks at 220-300 micromoles per liter, injections can reach over 15,000 micromoles per liter, delivering therapeutic concentrations impossible through oral routes

continued 5.5% additional loss in tirzepatide continuation group SURMOUNT-4: Weight maintenance trial confirming sustained benefits over extended treatment [1] November 2023: FDA Approval for Obesity Zepbound (tirzepatide) approved for chronic weight management in adults with obesity (BMI 30) or overweight (BMI 27) with weight-related comorbidities

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Obesity is highly associated with an array of non-communicable diseases including cardiovascular disease (CVD), type 2 diabetes, dyslipidemia, kidney disease, site-specific cancers, and musculoskeletal disorders [2, 3]