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In rare cases, patients can experience severe allergic reactions that need immediate medical attention

Some users also report low blood pressure after use which means that there is an indication that you should not use too much at one time

GSH is a tripeptide (-L-glutamyl-L-cysteinylglycine) synthesized by two cytosolic ATP dependent enzymes: glutamate cysteine ligase (GCL) leading to the production of -glutamyl-cysteine from glutamate and cysteine and glutathione synthetase (GS) involved in the ligation of -glutamyl-cysteine to glycine to produce -glutamylcysteinylglycine

Biol Chem 384:50516 Lu GD, Shen HM, Chung MC, Ong CN (2007) Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells