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Although HQ can function as an alternative substrate for TYR, the subsequent enzymatic reaction results in the production of reactive oxygen species (ROS), which is thought to be responsible for its skin-lightening properties, with possible associated side effects including leukoderma and exogenous ochronosis (82,83)

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Efficacy, safety, and cost of Goeckerman therapy compared with biologics in the treatment of moderate to severe psoriasis