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Portacolone E, Palmer NR, Lichtenberg P, et al

Phase 1 Trials In a first-in-human, randomized, placebo-controlled, single ascending dose, phase 1 trial in healthy participants, retatrutide demonstrated a favourable safety profile (similar to other incretin-based therapies) and early signs of efficacy with dose-dependent WL [42]

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In research contexts, peptide activity is typically discussed over extended exposure periods rather than instant results