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Surgeons and endoscopists have focused on the role of the mechanical or functional failure of the antireflux barrier, and this has become the prime target of various approaches for preventing the reflux of gastric contents into the esophagus

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Common side effects include: Injection site reactions pain, redness, or swelling at the injection site Mild diarrhoea or gastrointestinal upset usually transient Skin reactions itching or rash (uncommon) Hypokalaemia rare, occurring when severe megaloblastic anaemia is corrected rapidly Serious adverse effects are extremely rare but may include anaphylaxis in hypersensitive individuals

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