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They mitigate the oxidative damage to membrane phospholipids, such as phosphatidylcholine (PC) and sphingomyelin (SM), and restore ceramide (CER) synthesis, which promotes apoptotic pathways in melanoma cells without harming healthy melanocytes 162

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Instead, DIC mediates electro-neutral exchange of dicarboxylates or GSH for inorganic phosphate ( TISSUE-SPECIFIC FEATURES OF GLUTATHIONE IMPORT TO MITOCHONDRIA Previous studies in a renal proximal tubular cell line, NRK-52E, indicated that overexpression of OGC and DIC increased mGSH levels and protected against oxidant-mediated cell death (Xu et al., 2006)