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Along with other hormones, neurotransmitters, and genetic factors, melatonin is part of a complex chemical dance taking place every night, which can be easily disrupted and create the sleeping disorders seen so prevalently today

[DOI] [PubMed] [Google Scholar] 108.Dent-Acosta RE, Storm N, Steiner RS, San Martin J

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We have shown that effective pharmacologic inhibition of GPX4 in PTC cells with direct inhibitor RSL3 induces a robust activation of ferroptosis, increased DNA damage, impaired DNA damage repair response due to reduced p-NPM1 levels, decreased cell viability and cell migration, as well as suppressed spheroid formation and viability in vitro