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Animal model studies have preliminarily revealed that Clostridium colonization can curtail the overgrowth of pro-inflammatory microbiota, restore the intestinal mucosal barrier, and limit systemic translocation of bacterial LPS, ultimately reestablishing gut microbial homeostasis (206, 207)

Studies have demonstrated that FOXO4-DRI modulates multiple regulatory pathways, including insulin signaling, cell cycle control, and oxidative stress response

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In healthy adults, its activity declines with age, contributing to the progressive loss of synaptic density and cognitive flexibility that most people experience starting in their 40s and 50s