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Several studies have shown that anti-EpCAM antibodies limit therapeutic efficacies as the results of showing dose- and target-dependent in metastatic cancers, short serum half-life, altered EpCAM expression pattern, and differential cleavage and localization of EpICD in cancer cells (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 126.Tansey JT, Huml AM, Vogt R, Davis KE, Jones JM, et al

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