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Multiple internal standards shall be used to evaluate the efficiency of every analytical step, as well as a quality control sample spiked at the MRPL with all (available) reference compounds

The GLP-1 component is also the primary driver of the gastrointestinal side effects that make gradual dose escalation necessary

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28 The cross-linkage and gellation of the solution form a matrix that is retained on the ocular surface by hydrophobic bonding to dry areas, as demonstrated by the reduction in corneal staining in clinical trials