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The D-amino acid substitution preserves the spatial orientation of amino acid side chains needed for competitive binding to the FOXO4-p53 interaction surface, maintaining biological activity despite the non-natural backbone (PMID: 28340339)

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tb , only a small portion of about 5-10% develop the disease in their lifetime ( The standard therapeutic regimen to treat active TB recommended by the Center for Disease Control and Prevention (CDC) is a multidrug regimen of antibiotics taken from 6 to 9 months known as DOTS (Directly Observed Treatment, Short-course) ( One approach to combat M