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Moreover, the combined treatment of these two agents proved more effective than single interventions, suggesting potential synergistic effects (Mobasher et al., 2022)

Therefore, to further assess the effect of metformin on both rectal cancer and normal, non-cancer rectal tissue, the protein secretome of treatment nave rectal tumour biopsies and non-cancer biopsies was assessed following metformin treatment

The mitochondrial membrane permeabilization results in the release of the proapoptotic factors from the mitochondrial intermembrane space, cytochrome c [194], AIF [195], and endonuclease G [196], to the cytosol

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