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The apparent K D values of the dimeric macrocycles determined by SPR remained in a similar range to the parental peptides (Supplementary Table 2 and Supplementary Fig

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But over the years reports have piled up about the occasional side effects of various antibiotics, including tendonitis, inner-ear problems and hearing loss, diarrhea, impaired kidney function, and other problems

Molecular Characteristics Complete Specifications: CAS Registry Number: 946870-92-4 Molecular Weight: 9,117.5 Da Molecular Formula: CHNOS Sequence Length: 83 amino acids (native IGF-I is 70 amino acids) Modifications: 13-amino acid N-terminal extension + Arg3Glu substitution Peptide Classification: Synthetic IGF-I analog, Long R3 variant Appearance: White to off-white lyophilized powder Solubility: Dilute acid (0.1M acetic acid) The peptides structure consists of native IGF-Is 70-amino acid sequence with two critical modifications