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Elevated pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-), interleukin (IL)1, and IL-6 in patients with depression may disrupt emotional regulation by crossing the bloodbrain barrier [15], while depressive behaviors can further exacerbate inflammation [16]

Cardiovascular effects of phentermine and topiramate: a new drug combination for the treatment of obesity

doi: 2 10.1016/j.pathol.2018.1011.1004

pylori infection of GC cells to produce transcriptionally inactivated HSF-1/STATs complex, which inhibits HSP70 expression, loses its cytoprotective function, and becomes less vulnerable to apoptosis induction (Pierzchalski et al., 2006)