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A 2021 Nature Communications study then showed that MOTS-c is induced by exercise and that treating mice, including animals started late in life, boosted running capacity and physical performance across young, middle-aged, and old groups [3]

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This is why a rolled ankle at 25 can turn into a chronically unstable ankle at 45, and why tennis elbow, plantar fasciitis, and rotator cuff tendinopathy have a maddening habit of hanging around for a year or more