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Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity

When collagen breaks down, fragments of it called matrikines bind to fibroblast receptors and trigger new collagen production as a repair signal

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Whereas ablation of a segment of the uterosacral ligament has not proved effective, randomized, controlled trials have shown the superiority of laparoscopic ablation of endometriotic tissue combined with presacral neurectomy (removal of the nerve bundle within the boundaries of the interiliac triangle) over laparoscopic ablation alone in improving dysmenorrhea and reducing severe midline pain (20)