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Dietary folate deficiencies and drugs that interfere with folate metabolism, eg, methotrexate, an anti-carcinogenic agent that inhibits dihydrofolate reductase, and nitrous dioxide (N 2 O), an anesthetic gas that inhibits methionine synthase activity, lead to accumulations and cellular effluxes of homocysteine, causing increases in circulating homocysteine levels (Ueland and Refsum, 1989)

Acute and subchronic toxicity studies in rats have not revealed significant toxicity at the therapeutic doses studied

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Patients sourcing unverified peptide compounds from overseas vendors without physician oversight are exposed to real contamination risks, dosing inaccuracies, and the absence of any clinical safety net