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Common Deficiency Symptoms Common symptoms of Vitamin B12 deficiency include: Fatigue Weakness Pale skin Shortness Mouth Issues: Sore, red tongue, mouth ulcers, bleeding gums Gastrointestinal: Loss of appetite, weight loss, nausea, diarrhea, constipation Nerve issues like numbness/tingling Mood changes (depression, irritability) Memory problems Key Differences: NAD+ vs B12 NAD+ and B12 both boost energy, but NAD+ acts as a deep cellular, anti-aging repair agent, while B12 provides immediate metabolic energy and red blood cell support

In addition to diet and exercise, functional supplements are often chosen to support this process

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The knockdown of BECN1 in HK-2 cells resulted in a significant decrease in lipid peroxide levels, a significant decrease in ROS levels, and a significant increase in GPX4 levels