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doi: 10.1002/path.5358 32 ChenS.NiuC.LvW

Proactively boosting your NAD+ levels via IV infusion can reduce your risk of life-threatening endothelial damage from the COVID-19 pathogen and its treatment

Note that 2-PAM has an affinity for the acetylcholine anionic binding site on cholinesterase (right middle panel), which could explain the oxime related worsening of cholinergic side effects when 2-PAM is administered prior to the onset of action of atropine in the setting of organophosphate poisoning, by transiently preventing nerve-agent free cholinesterase from interacting with acetylcholine

Regulation of the TCA Cycle There is no direct hormonal regulation of TCA cycle activity