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The process begins with genetic susceptibility, primarily caused by high-risk HLA class II alleles (e.g., HLA-DQ2/DQ8), and is complemented by class I alleles and key non-HLA variants in immunoregulatory genes

In some embodiments, the otic formulation or composition comprises about 6% by weight of the cholesterol

There is no published guidance on monitoring, no validated stopping rule, and no human safety threshold to reference

* Correspondence: Hongying Kuang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers