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According to the Centers for Disease Control and Prevention (CDC), excessive acetaminophen consumption is a leading cause of acute liver failure, making routine monitoring essential

Bile acid imbalance can also promote mucosal inflammation and barrier damage by altering intestinal epithelial cell permeability and regulating the balance of immune cells (Shi et al., 2023)

5.3 Metabolic and barrier dysfunction The oral microbiota dysbiosis associated with periodontitis disrupts the intestinal microenvironment through metabolic regulation and impaired barrier function, contributing to the pathogenesis of depression

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