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In a study of 49 patients desiring pregnancy, 51% (25/49) achieved pregnancy after discoid excision, with a high spontaneous pregnancy rate of 60% (15/25) and a live birth rate of 75% (12/16) among spontaneous conceptions

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Moreover, a systematic review and meta-analysis of observational studies demonstrated that blood levels of copper in patients with depression were higher than those of patients without depression, while there was no difference in copper content in the hair between the two groups, suggesting that copper levels in the blood may be more sensitive to pathological changes in patients compared to those in the hair (Harvey et al., 2009