gliotoxin and glutathione from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase: Cell Chemical Biology Gliotoxin - Wikipedia

Int J Mol Sci 23

10.31083/j.fbl2809209 39 HeckerL.ChengJ.ThannickalV

In diseases linked to FAD deficiency or disrupted riboflavin metabolism, like L-2-HGA and AIFM1-related encephalopathy, aberrant chromatin states and DNA methylation patterns have been observed, underscoring a tight connection between riboflavin availability and gene expression regulation

Using a long-term HFD-fed mouse model of NAFLD, we demonstrated in this study that NAFLD development occurs concomitantly with dysregulated hepatic glutathione homeostasis characterized by decreased GSH and increased GSSG, and increased TNF protein levels in both the circulation and the liver