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Three multicenter double-blind, placebo-controlled, phase 3 trials (TARGET 13), had demonstrated the efficacy and safety of rifaximin in improving the symptoms of IBS

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38 This pain commonly presents as spontaneous burning sensations in the feet, and patients may also report positive sensory symptoms such as brush-evoked allodynia (pain from normally non-painful stimuli) and paresthesias, which are often accompanied by sensory loss, leading patients to describe the paradox of their feet being continuously painful yet insensate to touch