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4 Conclusion In general, the auto-reactive cellular immune responses including osteoclasts, synovial fibroblasts, T cells, B cells, NK cells, macrophages and DCs, play major roles in RA pathogenesis, although soluble inflammatory and rheumatoid factors with inflammatory natures were also involved

Before considering peptide therapy, patients undergo a detailed medical evaluation, including review of medical history, current medications, and appropriate laboratory testing

doi: 10.1007/s00018-005-4560-2

Studies have shown HGF possibly stimulating this function and suggesting its positive role in immunotherapy [7274]