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Kidney damage: Long-term use contributes to renal dysfunction, especially in those with preexisting kidney issues

190 , 204 Therefore, it is feasible to use AMPs as the ligands to modify the surface of drug-loaded nano preparations in order to improve the cell penetration ability, tumor-targeting ability, and the tumor cell uptake rate the nanoparticles, thus promoting drug action

HSP60 also modulates the folding and function of TRiC client proteins, including STAT3, cyclins B and E, p53, and Von HippelLindau (VHL) protein

Primary fragment screening by LO-NMR Whilst the XChem screen highlighted the possibility of obtaining hit matter in the TIN2 TBM leucine pocket of TRF1 TRFH , it also raised questions about the tractability of the fragment hits obtained using the available crystal system, especially given the crystal contacts and poor hit confirmation rate by the orthogonal CPMG assay