(12)Fmoc-Pro-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val- (12) Preparation of Fmoc-Pro-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-resin: (11)Fmoc-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-1050530105010603DMF3DMF2DMFFmoc-Pro-OHDIEATBTU/HOBtHBTU/HOBtBOP/HOBt105010603DMF3DMF2Fmoc-Pro-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val- In the Fmoc-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-resin in step (11), add the decapping reagent and react at 1050C 5 to 30 minutes, dry with a vacuum pump, re-add the decapping reagent at 10 to 50 C for 10 to 60 minutes, dry, wash with isopropanol for 3 times, DMF for 3 times, re-distilled DMF for 2 times, add Dissolve Fmoc-Pro-OH, DIEA, TBTU/HOBt or HBTU/HOBt or BOP/HOBt mixture in DMF, react at 10-50C for 10-60 minutes, dry with vacuum pump, wash with isopropanol 3 times, DMF Washed 3 times, washed 2 times with re-distilled DMF, and dried to obtain Fmoc-Pro-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu- Val-resin
This pattern indicates that AOD-9604 produces minimal additional symptom burden beyond what would be expected in the absence of treatment
Individual responses to glutathione can vary
[229 230] We are conducting a review of the patient safety and healthcare-associated infection measures and the scoring and weighting methodology, as part of our ongoing efforts to evaluate and strengthen the HAC Reduction Program
