Across developmental, acute, and regional manipulations, elevated KYNA consistently reduces extracellular glutamate in both the hippocampus and prefrontal cortex [30, 74, 75, 81]
The hypothesis has expanded to include vascular dysfunction, oxidative stress, microglial activation, and impaired proteolysis (Roda et al., 2022)
Carnitene solution for infusion must be used with great caution in patients with congestive heart failure, severe renal insufficiency and in clinical conditions in which there is edema with salt retention, in patients treated with corticosteroids or corticotropins
In vivo experiments using murine colon carcinoma model revealed the treatment with PEG-MP7 significantly suppressed tumor growth