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This allows (2) capture by RHEB at a distance of ~1.54 nm from the membrane

Thus, RDW-SD is a more sensitive index than routinely used RDW% (RBC volume histogram width at 50% of the curve height to MCV ratio) in cases when a small number of macrocytes and microcytes appear in the RBC population because it measures the lower part of the MCV distribution curve compared to the RDW% 53

For example, 2D cultures only allow interactions with neighboring cells and the formation of cell-ECM adhesions on the substrate side in the horizontal plane, whereas in 3D culture, cells are capable of forming adhesions on all sides in a dynamic way [239]