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They present antigens, modulate T cell activation, and skew immune polarization toward Th17 and Th2 dominance, patterns commonly observed in autoimmune conditions

In particular, drug molecules can bind to the membrane and/or to proteins into the cytosol

They identified the iron storage protein, ferritin light chain 1 (FTL1), as a pro-ageing neuronal factor: its overexpression in the hippocampus of young mice accelerated cognitive decline, whereas knockdown in aged mice preserved synaptic integrity and prevented cognitive deterioration

(2022) "Metformin: Activation of 5' Amp-Activated Protein Kinase and Its Emerging Potential Beyond Anti-Hyperglycemic Action." Front Genet vol