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Causes include: Neurobiological factors (hypersensitivity of the ejaculatory reflex) Hormonal imbalances Inflammation or infection of the prostate or urethra Psychological factors such as anxiety, guilt, or depression Relationship issues Early sexual experiences that conditioned rapid ejaculation Many men with PE also develop secondary erectile dysfunction due to performance anxiety, creating a cycle that can be difficult to break without proper treatment

Science 341 (6143), 295298

Typical research doses of 250-500 mcg translate to 10-20 units, right in the practical sweet spot

Anxiety-like behavior during nicotine withdrawal predict subsequent nicotine consumption in adolescent C57BL/6 mice