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Elucidating these unanswered aspects will be critical for understanding how CYP51A1 contributes to alkaliptosis and for developing novel therapeutic interventions that target this pathway

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Post-MI depression notably reduces quality of life and is associated with a 2- to 2.5-fold increase in cardiovascular mortality (Yang et al., 2021)

It might be argued that for the long time scale of PD progression, apoptosis is an acute cellular event that on the surface does not perfectly explain the development of PD, but when patients start to have detectable parkinsonism symptoms, there is usually at least 4060% dopaminergic neuronal loss in the substantia nigra (Gigure et al., 2018), suggesting progressive accumulation of neuronal loss