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However, isotope-labeled IS are often expensive or unavailable for certain compounds and using a single isotope-labeled IS for multiple structurally diverse compounds is inappropriate due to differences in retention times, matrix effects, ion suppression, fragmentation patterns, and ionization efficiencies

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Primary metabolism of aflatoxin B 1 Once inside the body and for toxicity to occur, AFB 1 undergoes enzymatic conversion to electrophilic endo and exo stereoisomers of AFB 1 -8,9-epoxide by the action of mixed function mono-oxygenase enzyme systems, CYPs are an intensively studied family of enzymes with currently approximately 4,000 known members

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Biomass Bioenergy 71, 340349

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doi: 10.1210/jc.2012-3093 115

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