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On the other side, the -glutamyl-amino acids are converted into 5-oxoproline and the corresponding amino acid by -glutamyl cyclotransferase
Furthermore, studies have reported an aberrant activation of NRF2, a key antioxidant transcription factor involved in the regulation of critical antioxidants including glutathione, SOD, and CAT, leading to reduced antioxidant capacity (Davinelli et al., 2025) In ASD children, the oxidative stress is not only higher, but it manifests in a complicated new pattern concerning different types of ROS and antioxidants (Hirayama et al., 2020)
Epithalon exhibits dose-dependent antioxidant properties by upregulating key antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPX), and glutathione-S-transferase, providing cellular protection against oxidative stress
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