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Irritation is localized, dose-dependent, and usually improves with continued use at lower frequency

When consumed orally, glutathione must survive the harsh acidic environment of the stomach, navigate intestinal absorption barriers, and undergo first-pass metabolism in the liver before reaching systemic circulation

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*Correspondence: Qiuxin Chen, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers