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In order to understand the inhibitory mechanism, the binding mode of -thujaplicin was predicted using homology model of hTYR

13 biomarkers including -catenin, C-MYC, GATA-4, CXCL13, DAPK1, TIMP3, DC-SIGN, EGFR, PIM2, GRIN2B, SLC5A8, VCAM-1 and CDH1 are related to the development of gastric cancer, and six of them including -catenin, DC-SIGN, C-MYC, EGFR, CXCL13 and PIM2 have been reported overexpressed in gastric tissue from infected children and gastric cancer patients (73)

Cyclooxygenase oxygenates arachidonic acid to PGG2 and then converts PGG2 to PGH2 via peroxidase activity