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Macrophage-specific PDPN conditional knockout mice showed reduced lymph angiogenesis and lymph invasion in breast cancer [115]

Treatment response depends on deficiency severity, route of administration, underlying cause, patient age, concurrent medical conditions, and medication interactions

Always consult with a healthcare provider before starting any new treatment to ensure it aligns safely with your health status and medical history

A deeper understanding of these interconnected metabolic networks clarifies the critical role of ferroptosis in OA progression and lays a robust foundation for integrated therapeutic strategies targeting both metabolic reprogramming and ferroptosis