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Long-term safety hasnt been studied

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The results of many preclinical studies of Rhodiola rosea and Withania somnifera (discussed explicitly in Section 5.2) revealed that they exhibit anti-neuroinflammatory and neuroprotective effects in vitro and in vivo experimental models of neuroinflammation, targeting numerous mediators of inflammation interacting on various levels of regulation of cellular and organismal homeostasis underlying acute inflammation initiation, transition, resolution, and repair

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