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(1998), ipamorelin activates the growth hormone secretagogue receptor (GHS-R1a) on pituitary somatotrophs without significantly stimulating ACTH, cortisol, prolactin, or aldosterone secretion a selectivity profile not achieved by earlier GHRPs including GHRP-2, GHRP-6, or hexarelin

*Correspondence: Giulia Di Benedetto, [email protected] These authors have contributed equally to this work These authors share senior authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Hence, the results of the meta-analysis may indicate reduced vagal modulation in ME/CFS, along with increased sympathetic modulation of heart rate (329)

This immune-boosting effect is particularly important for maintaining health and vitality in the later stages of life