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In Class 1, HDACs 1, 2, 3, and 8 are clustered based on their similarity to yeast transcriptional regulator, reduced potassium deficiency 3 (Rpd3) (Wiech et al., 2009) while HDAC 8 is found to be expressed in smooth muscle and plays a key role in muscle contractility

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Reduced Oxidative Stress: Neutralizes free radicals to lower overall cellular inflammation