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Some older animal studies highlighted in a For example, one study found that applying creams containing varying levels of maca root extracts to mice led to less skin thickening

doi: 10.1016/j.freeradbiomed.2022.04.005 61 KoYCChoiHSKimSLYunBSLeeDS

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In summary, although targeting Gln metabolism is a promising therapeutic approach, a more comprehensive strategy that addresses interconnected resistance mechanismssuch as ECM remodeling, HIF signaling, and CAFmediated immunosuppressionis essential to improve drug efficacy and overcome resistance in PC