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Change history 11/15/2025 A Correction to this paper has been published: 10.1007/s10522-025-10326-8 References Aina FO, Fadare JO, Deji-Dada OO, Agbesanwa TA (2021) Increasing burden of aging population on health services utilization: a myth or reality in a country with predominantly young population

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Relative contraindications requiring caution include active or suspected cancer (GHK-Cu promotes angiogenesis with concern about theoretically feeding tumors, though conflicting data shows documented anti-cancer gene expression effects requiring medical supervision), severe organ dysfunction (kidney or liver failure may slow peptide clearance), hemochromatosis or copper overload conditions, autoimmune disorders, and patients on immunosuppressants or blood thinners

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