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Alternatively, NPs are added to surfaces with microscale features, creating a hierarchical, dual-scale structure with microscale and nanoscale roughness (Figure 2)

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Recently, our group has demonstrated that PD mimetics including 6-hydroxydopamine (6-OHDA), N-methyl-4-phenylpridine (MPP + ) and rotenone suppressed mTOR signalling, accelerated cleavage of caspase-3 and PARP in PC12 cells and primary neurons and subsequently triggered neuronal apoptosis