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Moreover, advanced light-dark schedules in genetically predisposed mice (e.g., K-ras/p53 mutants) led to enhanced tumor growth and cell proliferation with increased oncogene c-Myc expression, while clock gene knockouts have tumor suppressive effects 203

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Beyond serving as substrates, KBs and ketogenic diets (KD) may enhance mitochondrial function by promoting mitochondrial biogenesis via NAD-dependent signalling pathways involving SIRT1/2/3, AMPK, PGC-1, and FOXO1/3a, and by increasing mitochondrial respiration through PGC-1mediated effects on respiratory complexes (e.g., complex I/II)

Cagrilintide works through amylin receptors (the CTR-RAMP complex), which are distinct from GLP-1 receptors but produce powerful appetite suppression through different signaling pathways, particularly in the area postrema of the brainstem