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Now, the timing may be different based on how low your B12 levels were to start with

Because absorption is limited, raising serum B12 with pills is a gradual, cumulative process that can take weeks or months of consistent daily use

What the body does to drugs APPARENT VOLUME OF DISTRIBUTION BIOAVAILABILITY CLEARANCE ELIMINATION HALF LIFE LOADING DOSE MAINTENANCE DOSE CLINICAL CORRELATES: Drugs that are significantly metabolized with one pass through the liver (and have a large extraction ratio) will have a low bioavailability when given orally

Vitamin B12 Deficiency Your body stores 1,000-2,000 times as much vitamin B12 as you'd eat in a day, so it can take many years to see symptoms of vitamin B12 deficiency