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But don't your joints feel just frozen at that point

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This led some authors to propose a chaperone competition model, in which aggregates, client, and metastable proteins (polyQ, huntingtin, ATXN1, and superoxide dismutase-1) rival for finite chaperone resources [64]

The research use version goes for roughly a fifth of that and is still enormously profitable, because bringing a real drug through trials to FDA approval is often estimated in the hundreds of millions of dollars, and by some counts well over a billion once you count the failures