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A 2017 double-blind, randomized study in 604 participants with knee osteoarthritis compared the effects of taking 800 mg/day of chondroitin sulfate, 200 mg/day of a popular NSAID known as celecoxib, and a placebo on osteoarthritis pain management ( After 6 months, chondroitin sulfate led to similar pain scores as celecoxib and significantly lower scores than the placebo

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However, factors like poor diet, stress, pollution, and aging can deplete glutathione levels